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Pradeep Moon Gunasekaran on Muck Rack

Pradeep Moon Gunasekaran

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Articles

Hypoxia-induced metastatic heterogeneity in pancreatic cancer

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By Qianqian Wang, Polina Guseva, Yoke-Chen Chang, Rajika Chauhan, Mengdie Xu, Gene Lee, Gregory Marshall, Siddharth Roy, Oscar Li, Arthur Roberts, Kelly Walton, Kishan Patel, Zhongren Zhou, Jian Cao, Wenjin Chen, Julie Zhouli Ni, Sam Guoping Gu, Cristina Montagna, Shin-Heng Chiou, Pradeep Moon Gunasekaran, Alexander Kley, Yousef Masoudpoor, Lucyann Franciosa, Shafiq Bhat, Emmanuel Zachariah
| Nature Verified
Abstract In solid tumors, hypoxia is a key driver of metastasis by promoting cellular plasticity and chromosomal instability (CIN). Despite this, the mechanisms by which malignant cells concurrently co-opt these elements of hypoxic adaptation to promote metastasis remains unclear. Here we report that hypoxia promotes metastasis by suppressing the JmjC-containing histone lysine demethylase KDM8.
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