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Letter to the editor in response to a letter by Fuchs and Santosham regarding; assessing safety and efficacy of a novel glucose-free amino acid oral rehydration solution for watery diarrhea management in children: a randomized, controlled, phase III trial
CorrespondenceVolume 81103111Open access aICDDR, B, Dhaka, Bangladesh bAmiLyfe Bioscience, LLC., Norwood, MA, USA Publication History: Received December 2, 2024; Revised January 27, 2025; Accepted January 28, 2025; Published March 4, 2025 DOI: 10.1016/j.eclinm.2025.103111Also available on ScienceDirect Copyright: © 2025 Published by Elsevier Ltd.
Assessing safety and efficacy of a novel glucose-free amino acid oral rehydration solution for watery diarrhea management in children: a randomized, controlled, phase III trial
Research in context Before this investigation, diarrhoeal disease was recognized as a leading cause of morbidity and mortality in children under the age of five, particularly in low- and middle-income countries, imposing significant healthcare burdens worldwide. Oral rehydration therapy (ORT), endorsed by global health organizations such as WHO, UNICEF, and USAID, has been the cornerstone of fluid replacement since 1978.
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