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Pravina Venkatesan on Muck Rack

Pravina Venkatesan

As seen in: Science Magazine, BioRxiv
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Articles

Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation

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By Ziyuan He, Marla C. Glass, Pravina Venkatesan, Marie L. Feser
| Science Magazine Verified
Editor’s summary Individuals who go on to develop rheumatoid arthritis (RA) experience a stage of disease development before clinical onset where they develop anticitrullinated protein antibodies (ACPAs). However, not all ACPA+ individuals go on to develop clinical RA. Here, He et al. investigated what distinguished those individuals who are ACPA+ and go on to develop disease.
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Systemic inflammation and lymphocyte activation precede rheumatoid arthritis

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By Ziyuan He, Marla C. Glass, Marie L. Feser, Pravina Venkatesan
| BioRxiv
Abstract Some autoimmune diseases, including rheumatoid arthritis (RA), are preceded by a critical subclinical phase of disease activity. Proactive clinical management is hampered by a lack of biological understanding of this subclinical "at-risk" state and the changes underlying disease development.
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