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Preben mortensen

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Articles

Changes in Genetic Contributions to ASD and ADHD by Year of Diagnosis

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By Sonja LaBianca, Mette Lise Lousdal, Morten Krebs, Ole Hansen, Kajsa-Lotta Georgii Hellberg, Mischa Lundberg, Johanne Østerby Sørensen, Jesper R. Gådin, Henrik Ohlsson, Jakob Grove, Anders D. Børglum, Esben Agerbo, Thomas Werge, Clara Albiñana, Bjarni J Vilhjálmsson, Kenneth S. Kendler, Oleguer Plana-Ripoll, Andrew J. Schork, Merete Nordentoft, Preben mortensen, Ditte Demontis, Anna Starnawska, Thomas Damm Als, Alfonso Buil, Anders H. Rosengren, Andres Ingasson, Dorte Helenius, Richard Zetterberg, Carsten Bøcker Pedersen, Jakob Christensen, Liselotte Pedersen, Marianne Giørtz Pedersen, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Alexandra Havdahl, Ángel Carracedo, Elemi J. Breetvelt, Elizabeth C Corfield, Hakon Hakonarson, Isabel Dziobek, Jack Underwood Verified, Javier González-Peñas, Jinjie Duan, Lauren Weiss, Ludger Tebartz van Elst, Michael J. Gandal, Ole A. Andreassen, Richard Anney, Stephen Scherer, Susan Kuo, Taylor Thomas, Vamsee Pillalamarri, Viktor H. Ahlqvist
| JAMA Psychiatry Verified
Changes in Genetic Contributions to ASD and ADHD by Year of Diagnosis Key Points Question Has the genetic risk profile of individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) changed as diagnostic rates have increased? Findings In this cohort study among 17 071 individuals with incident diagnosis of ASD and 20 111 individuals with incident diagnosis of ADHD, genetic contributions to ASD and ADHD diagnoses weakened over the past 2 decades.
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Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder - Nature Genetics

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By Clare Palmer, Morten Krebs, Vivek Appadurai, Esben Agerbo, Anders D. Børglum, David M. Hougaard, Preben mortensen, Kenneth S. Kendler, Terry L Jernigan, Daniel H Geschwind, Andrew Dahl, Søren Dalsgaard, Thomas Werge
| Nature Verified
Abstract Attention deficit hyperactivity disorder (ADHD) is a complex disorder that manifests variability in long-term outcomes and clinical presentations. The genetic contributions to such heterogeneity are not well understood. Here we show several genetic links to clinical heterogeneity in ADHD in a case-only study of 14,084 diagnosed individuals. First, we identify one genome-wide significant locus by comparing cases with ADHD and autism spectrum disorder (ASD) to cases with ADHD but not ASD.
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Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders - Translational Psychiatry

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By Clara Albiñana, Bjarni J Vilhjálmsson, Thomas Werge, David M. Hougaard, Anders D. Børglum, Preben mortensen, Vibe G. Frøkjær
| Nature Verified
Abstract It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark.
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