Preetida J. Bhetariya

Graphical Abstract Human Endoderm Development Stem cell differentiation is a critical process in early development and involves the activation and deactivation of genes. The cover art highlights the crucial role of NF2 in regulating endoderm differentiation in human induced pluripotent stem cells (hiPSC; bottom). Minjin Jeong, Dongjun Han, Konstantina M.

1 Introduction Embryonic development is a complex process regulated by a variety of signaling pathways, including Notch, transforming growth factor β (TGFβ), WNT/β -catenin, Hippo, receptor tyrosine kinase, and Hedgehog.[1] The protein merlin, encoded by the NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor (Nf2) gene in mice, is essential to segregate the inner cell mass from the trophectoderm in preimplantation embryo,[2] and helps orchestrate these pathways to ensure normal...

Brent S. Pedersen ORCID: orcid.org/0000-0003-1786-22161,2, Preetida J. Bhetariya1, Joe Brown1,2, Stephanie N. Kravitz1, Gabor Marth1, Randy L. Jensen3, Mary P. Bronner4, Hunter R. Underhill5 & Aaron R. Quinlan1,2,6 Genome Medicine volume 12, Article number: 62 (2020) Cite this article Abstract Background When interpreting sequencing data from multiple spatial or longitudinal biopsies, detecting sample mix-ups is essential, yet more difficult than in studies of germline variation.