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Prem Prashant Chaudhary on Muck Rack

Prem Prashant Chaudhary

As seen in: Wiley Online Library, PLOS ONE, MDPI, Science Magazine, Medical Brief
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Articles

TRPA1 Influences Staphylococcus Aureus Skin Infection in Mice and Associates with HIF-1a and MAPK Pathway Modulation

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By Manoj Kumar Yadav, Prem Prashant Chaudhary, Grace Ratley, Brandon N. D’Souza
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Shotgun metagenomic sequencing on skin microbiome indicates dysbiosis exists prior to the onset of atopic dermatitis

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By Prem Prashant Chaudhary, Ian A. Myles, Jordan Zeldin
| Wiley Online Library Verified
Abstract Background While the microbiome is increasingly seen as a targetable contributor to atopic dermatitis (AD), questions remain as to whether the dysbiosis is secondary to diseased skin or if it predates symptom onset. Previous work has evaluated how the skin microbiome changes with age and established the influence of factors like delivery mode and breastfeeding on global microbiome diversity. However, these studies were unable to identify taxa which predict subsequent AD.
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Diisocyanates influence models of atopic dermatitis through direct activation of TRPA1

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By Manoj Kumar Yadav, Prem Prashant Chaudhary, Brandon N. D’Souza, Grace Ratley
| PLOS ONE
TRPA1 effect on wound cultures are modulated by catecholamine signaling Bundling the identified features from MALDI analysis into pathways using the Metaboanalyst software [22] revealed that tyrosine metabolism was the most upregulated pathway in TRPA1-/- mice (Fig 5A). Tyrosine metabolism was also the most upregulated pathway when comparing the adjunct effects of TRPA1 blockade versus R. mucosa (Fig 5B–5D).
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