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Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways

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By Jiaxuan Li, Yuhong Zhang, Prevention Hangzhou P.R
| Wiley Online Library Verified
1 Introduction As global population aging accelerates, older adults face heightened susceptibility to infectious diseases due to immunosenescence and comorbidities, placing greater demands on preventive measures such as vaccination. According to United Nations data, by 2050, individuals aged 65 and older are projected to account for more than 16% of the global population, a substantial rise from 9% in 2020.
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