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Primal de Lanerolle

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Articles

Effects of altered gravity on adrenergic-mediated cAMP signalling in intact cells

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By Marc Bathe-Peters, Iqra Sohail, Alexei Sirbu, Katharina Schneider, Tommaso Patriarchi, Anantha Anilkumar, Paolo Annibale, Yannick Lichterfeld, Christian Liemersdorf, Primal de Lanerolle
| Nature Verified
Abstract Spaceflight-induced cardiac atrophy and rhythm disorders are linked to dysregulation of the adrenergic-cAMP-PKA pathway. Gravity-dependent alterations in adrenergic signaling, particularly cAMP dynamics, remain poorly understood. Using fluorescence biosensors, we studied intact cells under simulated microgravity and hypergravity.
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