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Parkinson's disease (PD) is the most common neurodegenerative movement disorder worldwide, with a current prevalence of over 6 million individuals that is projected to double over the next 30 years.1 PD is a synucleinopathy, pathologically defined by the formation and accumulation of α-synuclein enriched Lewy bodies and Lewy neurites in various brain regions, along with the progressive degeneration of dopamine producing neurons in the substantia nigra.
Parkinson's disease (PD) is the most common neurodegenerative movement disease with a global prevalence of approximately 8.5 million cases. PD is clinically characterized by loss of dopaminergic neurons, causing motor symptoms of rest tremor, rigidity, and bradykinesia. It is pathologically characterized by the presence of α-synuclein aggregates in neurons. PD is a complex polygenic disease, with more than 20 genes implicated in the disease process.
This protocol was designed to maximize the generation of ionizable molecular species while eliminating delocalization of analytes. The key factors involve using the same overriding principle when applying matrix, digesting the sample, or recrystallizing after sublimation24; namely, that an even deposition of vapor, matrix or otherwise, needs to be created and maintained.
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