Projit Mukherjee on Muck Rack

Projit Mukherjee

As seen in: BioRxiv
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Articles

DNA Polymerase α has pyrimidine dimer translesion activity that is suppressed during normal replication

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By Grant D. Schauer, Projit Mukherjee, Abheerup Sarker
| BioRxiv
Abstract DNA is damaged by UV light, forming lesions like pyrimidine dimers which impede DNA replication forks and can cause mutations that lead to cell death or cancer. To ensure rapid and accurate DNA replication during S-phase, the cell uses so-called DNA damage tolerance (DDT) pathways to bypass this damage, leaving lesions to be repaired after completion of replication.
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