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Pu Xing

As seen in: Nature, Wiley Online Library, Canadian Journal of Infectious Diseases & Medical Microbiology
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Articles by Pu Xing

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

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By Xiaowen Qiao, Pu Xing, Jiangbo Chen, Lin Song
| Wiley Online Library Verified
1 Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies in the digestive system,[1] characterized by high rates of relapse, metastasis, and heterogeneity, making clinical management challenging.[2] Immune checkpoint blockade (ICB), especially the anti-PD-1 therapy, has significantly changed the landscape of CRC therapy.[3, 4] However, a large number of patients still fail to respond to the ICB monotherapy due to primary or acquired drug resistance.[5-7] Hence,...
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MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

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By Pu Xing, Jiangbo Chen, Xinying Yang, Xiaowen Qiao
| Wiley Online Library Verified
1 Introduction Colorectal cancer (CRC) is the third most prevalent cancer and the second leading cause of cancer-related mortality worldwide.[1] As the primary cause of death in CRC,[2] distant metastasis occurs in ≈50% of CRC patients, with liver metastasis being particularly common.[3] However, the molecular mechanisms of CRC metastasis remain poorly understood and must be unraveled if we are to develop new interventional therapies to improve outcomes in patients.
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WFDC3 inhibits tumor metastasis by promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer - Cell Death & Disease

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By Tianqi Liu, Min Zhao, Jiangbo Chen, Pu Xing, Pin Gao, Lei Chen, Beihai Jiang
| Nature Verified
Abstract Estrogen plays a protective role in colorectal cancer (CRC) and primarily functions through estrogen receptor β (ERβ). However, clinical strategies for CRC therapy associated with ERβ are still under investigation. Our discoveries identified WFDC3 as a tumor suppressor that facilitates estrogen-induced inhibition of metastasis through the ERβ/TGFBR1 signaling axis. WFDC3 interacts with ERβ and increases its protein stability by inhibiting its proteasome-dependent degradation.
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A birdstrike risk assessment model and its application at Ordos Airport, China

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By Yuanyuan Hu, Fan Yang, Gang Feng, Pu Xing
| Nature Verified
Abstract Birdstrikes are an important threat to aviation safety. A standardized, scientific process for assessing birdstrike risk could prevent accidents, thereby improving the flight safety and reducing economic losses. However, China currently lacks a unified birdstrike risk assessment system. Here, we propose and validate a new model for assessing birdstrike risk in order to fill that need. The model consists of two elements.
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