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Highlights • PAD2 is increased upon OL differentiation • OL differentiation is facilitated by PAD2-mediated chromatin remodeling in myelin genes • PAD2 contributes to efficient myelination and motor and cognitive functions • Nuclear and myelin proteins interact and are citrullinated by PAD2 Summary Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases.
a) Molecule and gene count of the remaining 1545 cells. Black squares and error bars within each cluster represent the average values andstandart deviation). Clusters were hierarchically reordered to represent the relation between the 30 clusters (Number of cells for each cluster from left to right: 32, 34, 34, 34, 24, 75, 105, 77, 34, 129, 61, 35, 38, 34, 22, 18, 87, 145, 11, 19, 51, 39, 67, 85, 66, 48, 56, 34, 41, 11).
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