Qi Leng

ACSL4 acyl-CoA synthetase long-chain family member 4 BBB blood–brain barrier CoQ10 coenzyme Q10 (ubiquinone) CSF cerebrospinal fluid DAMPs damage-associated molecular patterns DFO deferoxamine DMT1 divalent metal transporter 1 ETC electron transport chain FSP1 ferroptosis suppressor protein 1 (also AIFM2) GPX4 glutathione peroxidase 4 GSH glutathione HO-1 heme oxygenase-1 I/R ischemia–reperfusion IONPs iron oxide nanoparticles Lip-1 liproxstatin-1 LIPC (4-HNE) 4-hydroxynonenal (lipid...

1 Introduction Keloid, a fibroproliferative reaction to wound healing in which scar tissue grows beyond the original wound margin following skin injury or irritation, belongs to a special category of pathological scars [1, 2]. Characterized by masses that protrude over the normal skin surface beyond the site of the original injury, keloids show persistent growth, a hard texture, poor elasticity, and a growth pattern similar to tumors.