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Articles by Qi Pan
Chain of thought driven reinforcement alignment with KAN for multimodal sentiment analysis of tourist reviews
Abstract Multimodal aspect-based sentiment analysis integrates text, images, and emojis to capture fine-grained emotional tendencies, making it particularly useful for social media opinion analysis and user experience evaluation. Traditional feature-level fusion networks, however, are easily corrupted by visual noise and lack explicit explanations for their emotional logic. At the same time, generative large language models, while capable of logical reasoning, are prone to hallucinations.
Interfacial Raft-Like Structures From Bottlebrush Polymers
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description anie74009-sup-0001-SuppMat.pdf1.2 MB The Supporting Information is available free of charge.
IL10RB-AS1 promotes pro-caspase-1-dependent pyroptosis via regulating the oligomerization and nucleation of CARD8 C-terminal domain to suppress acute myeloid leukemia
Abstract CARD8 (caspase activation and recruitment domain-containing 8) senses intracellular danger signals, leading to inflammasome formation and pyroptosis. Recently studies have shown that CARD8 was highly expressed in hematopoietic cells, however, the mechanism by which the released C- terminal domain of CARD8 (CARD8-CT) oligomerizes and nucleates, and its role in acute myeloid leukemia (AML) treatment has not been fully understood.
Immune monitoring, immune phenotyping, and precision intervention in severe pneumonia: current evidence and translational challenges
Abstract Severe pneumonia remains a major cause of mortality in critically ill patients, with severe community-acquired pneumonia representing a clinically important and representative scenario. This review focuses primarily on severe community-acquired pneumonia as the clinical context, in which outcomes are determined by the interplay between pathogen burden and heterogeneity of host responses.
A unified ligand-dimensional design to halt cation migration in perovskite photovoltaics
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Organic cation migration, particularly that of formamidinium (FA+), remains a major factor limiting the long-term stability of perovskite solar cells (PSCs).
A novel gain-of-function mutation (W818R) of calcium-sensing receptor in a family with autosomal dominant hypocalcemia type 1
Abstract Introduction: Autosomal dominant hypocalcemia type 1 (ADH1) is a rare inherited disorder caused by gain-of-function mutations in the calcium-sensing receptor (CASR) gene, with clinical manifestations ranging from asymptomatic hypocalcemia to recurrent seizures. Methods: Clinical evaluation and genetic testing were performed. Through activation of the MAPK signaling pathway,cellular functional validation was conducted to confirm the pathogenicity of this variant.
Proteomic results indicate inhibition of complement cascades is one of the mechanisms underlying the protective effects of Tongxinluo against myocardial infarction
Abstract Objective: Tongxinluo (TXL), a traditional Chinese medicine, has demonstrated cardioprotective effects in acute myocardial infarction (AMI), yet its impact on myocardial protein profiles remains largely unexplored. This study aimed to elucidate the proteomic mechanisms underlying the therapeutic effects of TXL in AMI. Methods: AMI was induced via left anterior descending artery ligation in C57BL/6J mice. TXL was administered by oral gavage during the acute phase.
A genome-wide association study identifies EYA2 as a contributing gene for diabetic retinopathy in type 2 diabetes - Communications Medicine
Abstract Diabetic retinopathy (DR) is a complication of diabetes that affects the eyes. This study aims to identify the genetic variants associated with DR in type 2 diabetes (T2D) patients from the UK Biobank cohort (n = 16,988). We conducted a genome-wide association study (GWAS) of DR and integrated genomic results with multi-omics data to identify and prioritize susceptibility variants and genes. The findings are set to undergo validation in four replication cohorts.
CES is clear: People want tech to improve their everyday lives
Image. The new year often brings a lot of anticipation in the world of tech - it's that time of the year where discussions and predictions about new technology dominate conversations within the tech industry and its most avid customers. The Consumer Electronics Show (CES) is one annual event that perfectly captures this anticipation. From robotic butlers to the most innovative product demos, it’s a moment designed to capture the imagination of the tech industry.
Interpretable Aging Signatures in Human Retinal Cell Types Revealed by Single-Cell RNA Sequencing and Sparse Logistic Regression
Keywords aging retina single-cell RNA sequencing machine learning transcriptional regulation Abbreviations and Acronyms AC (amacrine cell) AMD (age-related macular degeneration) AO/PI (acridine orange/propidium iodide) AUC (area under the curve) BC (bipolar cell) BSA (bovine serum albumin) DB (diffuse bipolar cell) DEGs (differentially expressed genes) DM (diabetes mellitus) DR (diabetic retinopathy) ECM (extracellular matrix) FDR (false discovery rate) FMB (flat midget bipolar cell) GEMs...
The transcription factor PcDfd regulates expression of PcCCE5 involved in spirodiclofen resistance in Panonychus citri (McGregor)
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description ps70440-sup-0001-TableS1-S8-FigureS1.docxWord 2007 document , 932 KB Table S1. Primers of transcription factors for dual-luciferase assay. Table S2. Primers of PcCCE5 promoter for dual-luciferase assay. Table S3. Primers for site-directed mutagenesis. Table S4. Primers for RT-qPCR. Table S5. Primers for RNAi. Table S6.
The impact of end-of-life disability level on middle-aged and older adults’ utilization of medical services
ORIGINAL RESEARCH article Volume 13 - 2025 | https://doi.org/10.3389/fpubh.2025.1650570 This article is part of the Research TopicPublic Health Outcomes: The Role of Social Security Systems in Improving Residents' Health WelfareView all 99 articles Introduction During the final stages of life, middle-aged and older adults’ demand for medical services increases significantly as they cope with illnesses (1, 2).
A Printed 3D SERS Array with Hierarchical Micro/Nanostructures Enabled Hotspot Engineering for Ultrasensitive Bio‐Detection
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm71761-sup-0001-SuppMat.docx5.1 MB Supporting Information References 1, , , , , , , , , , , , , , Nat. Biotechnol. 2025, 43, 936. 2, , , , , , , , , , , Chem. Soc. Rev. 2025, 54, 1453. 3, , , , , , , , , , , Chem. Soc. Rev. 2024, 53, 5394. 4, , , , , , Angew. Chem., Int. Ed. 2025, 64, 202502115. 5, , , , , , , , , , , Nat. Commun. 2024, 15, 7975. 6, , , , , , , Nano Lett. 2024, 24, 11116.
Global exponential stabilization of underactuated surface vessel with high-order fully actuated control approach
1 INTRODUCTION In the past decade, surface vessel control has become a highly active research field [1], encompassing stabilization [2, 3], trajectory tracking [4, 5], formation control [6, 7], and more. The primary characteristic of underactuated unmanned surface vessels is that the number of independent actuators is less than the system's degrees of freedom, which complicates the design of stabilization control laws.
TPI1-loaded heart-homing polymeric nanoparticles alleviate acute myoca
Back to Journals » International Journal of Nanomedicine » Volume 20 Authors Pan Q , Chen G, Zhuang X, Li F, Yang Y Received 5 May 2025 Accepted for publication 29 July 2025 Published 27 August 2025 Volume 2025:20 Pages 10353—10367 DOI https://doi.org/10.2147/IJN.S533628 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Xing Zhang Qi Pan,1,* Guihao Chen,1,* Xiaoli Zhuang,2,* Fei Li,3 Yuejin Yang1 1State...
LoniComp: a platform for gene function comparison and analysis between Lonicera japonica and Lonicera macranthoides - BMC Genomics
Genomic data and genome annotation of L. japonica was obtained from the National Genomics Data Center (NGDC, https://ngdc.cncb.ac.cn/) (Accession number: GWHAAZE00000000), L. japonica (sijhua) Genomic data was obtained from the China National Gene Bank database (CNGBdb, https://db.cngb.org/) (Accession number: SAMN24662184), and the genome annotation file was obtained from the Figshare platform (https://figshare.com/). Transcriptomic data for L. japonica and L.
On the novel finding of two modified-Nix-Gao models for indentation size effect - Scientific Reports
Abstract Existing modified-Nix-Gao models have been developed to accurately describe the descending indentation size effect (ISE). This raises the question of whether the modified-Nix-Gao models can describe other types of ISE. In this paper, because Nix-Gao-Feng and Nix-Gao-Haušild models are exceptionally straightforward and user-friendly, the two modified-Nix-Gao models are chosen to make a systematic study.
Single-Cell Transcriptomics Reveals Dynamic Microglial States and Neural-Immune Networks in Human Diabetic Retinopathy
Abstract Diabetic retinopathy (DR) is a major cause of vision loss worldwide. Here, we perform single-cell RNA sequencing of thirteen human retina samples (from living and post-mortem donors) across non-diabetic, diabetic, and DR states to create a comprehensive transcriptomic atlas.
Novel Genetic Variants Associated with Gout Identified Through a Genome-Wide Study in the UK Biobank (N = 150,542)
The authors have declared no competing interest. This research was primarily supported by the Pioneer and Leading Goose R&D Program of Zhejiang Province 2023 (Grant No. 2023C04049) and the Ningbo International Collaboration Program 2023 (Grant No. 2023H025). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Refining the Safety Perspective of Bulevirtide in Chronic Hepatitis Delta Management
LETTER TO THE EDITOR Refining the Safety Perspective of Bulevirtide in Chronic Hepatitis Delta Management Bulevirtide Monotherapy Is Safe and Well Tolerated in Chronic Hepatitis Delta: An Integrated Safety Analysis of Bulevirtide Clinical Trials at Week 48 Tarik Asselah, Pietro Lampertico, Soo Aleman, Marc Bourlière, Adrian Streinu-Cercel, Pavel Bogomolov, Viacheslav Morozov, Tatiana Stepanova, Stefan Lazar, Dmitry Manuilov, Renee-Claude Mercier, Steve Tseng, Lei Ye, John F.
Poly(1,3‐dioxolane)‐Modified Li1.3Al0.3Ti1.7(PO4)3 as the Electrolyte for Enhanced Solid Lithium Metal Batteries
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description chem202403915-s1-Supporting_Information.pdf927.9 KB Supplementary
Palladium-Catalyzed Oxidative Allene–Allene Cross-Coupling
Introduction Click to copy section linkSection link copied! Transition-metal-catalyzed cross-coupling has proven to be one of the most important methods for the construction of C–C bonds. (1−7) In a classical C–C cross-coupling reaction (Figure 1A), an organohalide electrophile and an organometallic nucleophile (such as an organomagnesium, an organozinc, or an organoboron) are usually applied as partners, and stoichiometric amounts of metal salt are generated as waste.
Palladium-Catalyzed Oxidative Allene–Allene Cross-Coupling
Introduction Click to copy section linkSection link copied! Transition-metal-catalyzed cross-coupling has proven to be one of the most important methods for the construction of C–C bonds. (1−7) In a classical C–C cross-coupling reaction (Figure 1A), an organohalide electrophile and an organometallic nucleophile (such as an organomagnesium, an organozinc, or an organoboron) are usually applied as partners, and stoichiometric amounts of metal salt are generated as waste.
Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates
MATERIALS AND METHODS Amphioxus (B. floridae) obtained from a stock maintained by J.-K. Yu originating from Tampa, Florida, and all juvenile or adult animals regardless of genotype were housed in a temperature-controlled (19°C) facility at Xiamen University (115).
Pseudohalide Anion Surface Engineering for Mixed Cation Perovskite Nanocrystals
C: Physical Properties of Materials and InterfacesNovember 21, 2024 Jie Fu Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu 215123, People’s Republic of China Shuhua Chen Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu 215123, People’s Republic...
Fresh Human Retinal scRNA-seq Atlas Reveals a Novel Cone Subtype and Cellular Diversity
Abstract The human retina has a remarkable diversity of cell types, which is crucial for understanding the mechanisms underpinning visual development and function. While single-cell RNA sequencing (scRNA-seq) has advanced our understanding of retinal biology, most studies have relied on postmortem or frozen samples, potentially missing important transcriptional information.
Engineering strategies of plant-derived exosome-like nanovesicles: cur
Back to Journals » International Journal of Nanomedicine » Volume 19 Authors Li Y , Wang Y, Zhao H, Pan Q , Chen G Received 17 September 2024 Accepted for publication 23 November 2024 Published 30 November 2024 Volume 2024:19 Pages 12793—12815 DOI https://doi.org/10.2147/IJN.S496664 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Prof.
A Genome-wide Association Study Identifies Novel Genetic Variants Associated with Knee Pain in the UK Biobank (N = 441,757)
The authors have declared no competing interest. This research was primarily supported by the Pioneer and Leading Goose R&D Program of Zhejiang Province 2023 (Grant No. 2023C04049) and the Ningbo International Collaboration Program 2023 (Grant No. 2023H025). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Fronto‐parietal activity changes associated with changes in working memory load: Evidence from simultaneous electroencephalography and functional near‐infrared spectroscopy analysis
CONFLICT OF INTEREST STATEMENT The authors declare no competing interests. REFERENCES (2003). Working memory: Looking back and looking forward. Nature Reviews. Neuroscience, 4(10), 829–839. https://doi.org/10.1038/nrn1201 , , & (2024). Validation of a mobile fNIRS device for measuring working memory load in the prefrontal cortex. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology, 195, 112275.
Alantolactone facilitates ferroptosis in non‐small cell lung cancer through promoting FTH1 ubiquitination and degradation
CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES , , , & (2021). A comprehensive review of anticancer mechanisms of action of Alantolactone. Biomedicine & Pharmacotherapy, 136, 111231. , & (2020). Lung cancer 2020: Epidemiology, etiology, and prevention. Clinics in Chest Medicine, 41(1), 1–24. , , , , , , , , , & (2019).
Genome-wide association studies found CCDC7 and ITGB1 associated with diabetic retinopathy
The authors have declared no competing interest. This study was mainly funded by the Pioneer and Leading Goose R&D Program of Zhejiang Province 2023 with reference number 2023C04049 and Ningbo International Collaboration Program 2023 with reference number 2023H025. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Structural Insights into the Dynamic Assembly of a YFV sNS1 Tetramer
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Printed on‐Chip Perovskite Heterostructure Arrays for Optical Switchable Logic Gates
The use of optoelectronic devices for high-speed and low-power data transmission and computing has been considered in the next-generation logic circuits. Heterostructures, which can generate and transmit photoresponse signals dealing with different input lights, are highly desirable for optoelectronic logic gates. Here, the printed on-chip perovskite heterostructures are demonstrated to achieve optical-controlled “AND” and “OR” optoelectronic logic gates.
Genome-Wide Association Study Identifies Novel Genetic Variants Associated with Widespread Pain in the UK Biobank (N=172,230)
The authors have declared no competing interest. This study was mainly funded by the Pioneer and Leading Goose R&D Program of Zhejiang Province 2023 with reference number 2023C04049 and Ningbo International Collaboration Program 2023 with reference number 2023H025.
Excessive daytime napping increases the risk of NAFLD
Back to Journals » Nature and Science of Sleep » Volume 16 Authors Qiao X , Wang X, Guo L, Pan Q Received 10 May 2024 Accepted for publication 18 July 2024 Published 24 July 2024 Volume 2024:16 Pages 1067—1074 DOI https://doi.org/10.2147/NSS.S468444 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.
The effect of self‐designed metabolic equivalent exercises on cancer‐related fatigue in patients with gastric cancer: A randomized controlled trial
1 INTRODUCTION The latest report from GLOBOCAN indicated that there were approximately 1.08 million new cases of gastric cancer (GC) in the world in 2020.1, 2 In China, approximately 470,000 new cases are diagnosed with GC yearly, accounting for about 8% of all cancer incidences.3 With advancements in medical technology, the cure and survival rates for patients with GC are increasing year by year.4-7 Therefore, more attention should be paid to the quality of life of patients with GC.8...
The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution
Research Article VIROLOGY Qi Pan https://orcid.org/0000-0001-6580-2731, Haizhan Jiao https://orcid.org/0000-0002-5249-2276, [...] , Wanqin Zhang https://orcid.org/0009-0008-1598-5187, Qiang Chen https://orcid.org/0000-0002-0467-4163, [...] , Geshu Zhang https://orcid.org/0009-0002-4539-080X, Jianhai Yu https://orcid.org/0000-0002-2986-8028, Wei Zhao https://orcid.org/0000-0003-1414-4438, and Hongli Hu https://orcid.org/0000-0003-3658-272X honglihu@cuhk.edu.cn+5 authors +3 authors fewerAuthors...
A Genome-wide Association Study Identifies Novel Genetic Variants Associated with Neck or Shoulder Pain in the UK Biobank (N = 441,757)
The authors have declared no competing interest. This study was mainly funded by the Pioneer and Leading Goose R&D Program of Zhejiang Province 2023 with reference number 2023C04049 and Ningbo International Collaboration Program 2023 with reference number 2023H025. This work was also supported by the European Union's Horizon 2020 research and innovation programme under grant agreement No 633491 (DOLORisk).
Ligand-Controlled, Nickel-Catalyzed Stereodivergent Construction of 1,3-Nonadjacent Stereocenters
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX CCDC 2240401–2240402 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033.
Stilbenes-enriched peanut sprouts alleviated physical fatigue via regulating interactions of nutrients-microbiota-metabolites revealed by multi-omics analysis - Food & Function (RSC Publishing)
Stilbenes-enriched peanut sprouts alleviated physical fatigue via regulating interactions of nutrients–microbiota–metabolites revealed by multi-omics analysis† In this study, the antifatigue effect and mechanism of peanut sprouts were explored. BALB/c mice divided into three groups (control, dark and UV-C) were respectively supplemented with a normal diet, peanut sprouts (dark germination) added diet and stilbenes-enriched peanut sprouts (UV-C radiated germination) added diet.
Brush-like Co/CoSe nano-heterostructures embedded in N-doped carbon for rechargeable Zn-air batteries
Brush-like Co/CoSe nano-heterostructures embedded in N-doped carbon for rechargeable Zn-air batteries Rational design and preparation of high-performance bifunctional oxygen electrocatalysts with effective sites and excellent mass/electron transfer structure are in demand for the Zn-air batteries to overcome the sluggish oxygen reduction/evolution kinetics.
Identification and Functional Characterization of an Omega-Class Glutathione S-Transferase Gene PcGSTO1 Associated with Cyetpyrafen Resistance in Panonychus citri (McGregor)
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Identification and Functional Characterization of an Omega-Class Glutathione S-Transferase Gene PcGSTO1 Associated with Cyetpyrafen Resistance in Panonychus citri (McGregor)
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
The clinical value of glycosylated hemoglobin level in newly diagnosed ketosis-prone type 2 diabetes
Introduction Among the acute complications of diabetes, ketosis or ketoacidosis (DKA) is a serious medical emergency which may lead to serious complications or even fatal consequences if not managed in time. It is usually considered to be the typical feature and first manifestation of Type 1 diabetes mellitus (T1DM) which is caused by the destruction of islet beta cells due to autoimmunity (1).
Triple Hybrid Cellular Nanovesicles Promote Cardiac Repair after Ischemic Reperfusion
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Seriously non-thermal thermodynamics - Nature Materials
Non-equilibrium thermodynamics describes activity-stabilized mixed states in complex active-matter systems. It was a truth universally acknowledged when we were younger that to implement honest thermodynamics about the real world would be just a fantasy. To attempt this would be an effective way to fail our exams, unless we chose toy models. But in two recent papers1,2, experiments and theory agree when this spirit of analysis is applied to phase separation in a generic biomolecular system.
Medications and medical expenditures for diabetic patients with osteoporosis in Beijing, China: A retrospective study
This study aimed to clarify the changes in treatment regimens and medical expenditures in diabetic patients with osteoporosis. We recruited 2,853,036 diabetic patients from the Beijing medical insurance database between 2016 and 2018. Among them, 406,221 patients also had osteoporosis. Clinical characteristics, treatment regimens, and medical costs were investigated in diabetic patients with and without osteoporosis. Diabetes and osteoporosis were most prevalent in participants aged 45−84 years.
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