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Qianxue Wu

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Articles

Fibroblast-specific ablation of MHC-I antigen presentation via the IGF2 axis cripples CD8 + T cell surveillance in lung cancer

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By Duncan J Berger, Xinwei Guo, Bingjie Zhang, Daqiang Song, Xiaofang Li, Qian Xiao, Hongtao Tie, Qianxue Wu, Yu Shi, Guomin Ye, Jiazheng Sun, Jiazhou Liu, Mingjing Chen, Zhu Qiu, Weiyan Peng, Long Meng, Guosheng Ren, Jing Huang, Hongzhong Li
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract How cancer-associated fibroblasts (CAFs) dictate CD8+ T cell dysfunction during lung cancer remains unclear. Through single-cell analysis of 84 human NSCLC samples, we identified insulin-like growth factor 2 (IGF2) as a key immunosuppressive factor in a specific CAF subset.
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