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Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort
Discussion This is the first clinical investigation to examine the long-term effects of GLP-1RA on KOA in patients with comorbid T2DM. We noticed significant differences in PROs pertaining to the WOMAC score, both total and pain subscale, between the GLP-1RA and non-GLP-1RA groups. Furthermore, the cartilage loss velocity and knee surgery incidence were both statistically lower in the GLP-1RA group.
Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort
Statistical analysis Continuous and categorical variables are presented as means±SD and counts (percentages), unless otherwise indicated (median (quartile)). Univariate analyses were conducted using the t-test (or Mann-Whitney U test) and Pearson’s χ2 test (or Fisher’s exact test). Multivariable regression models (linear or logistic regression) were used to compare the mean changes in related variables and knee surgery incidence between the GLP-1RA therapy and non-GLP-1RA therapy groups.
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