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Qiaoli Lang

As seen in: BioRxiv
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Articles

Gardenin A improves cognitive and motor function in A53T-α-syn mice

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By Wyatt Hack, Noah Gladen-Kolarsky, Swarnali Chatterjee, Qiaoli Lang
| BioRxiv
Abstract Oxidative stress and neuroinflammation are widespread in the Parkinsons disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The polymethoxyflavone Gardenin A (GA) has been shown to activate the NRF2-regulated antioxidant pathway and inhibit the NFkB-dependent pro-inflammatory pathway in a Drosophila model of PD.
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