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Qiaoyong Yi

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Articles

Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice

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By Florian Jaudas, Hongye Wang, Sebastian N. Roemer-Cassiano, Zhaorong Wu, Dan Cui, Zhigang Zheng, Haigang Geng, Zhen Sun, Yixiao Pan, Yaoping Shi, Zhenyu Song, Yantao Li, Kangjie Shen, Weiming Shen, Hexin Yan, Ruidong Hao, Minmin Sun, Linke Bian, Jiufei Zhu, Qiaoyong Yi, Shuangshung Zhang
| Science Magazine Verified
Editor’s Summary A major challenge in developing CAR-T cell therapies for solid tumors is that solid tumors generally lack unique targets that are not expressed on healthy tissue. One way to circumvent that problem is to exploit the differential migration of CAR-T cells into tumor versus healthy tissue. Here, Wang et al. do just that by deleting genes required for CAR-T cell migration into healthy tissue.
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