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Does fish oil supplementation increase cholesterol efflux capacity in familial hypercholesterolaemia?
1 INTRODUCTION Familial hypercholesterolaemia (FH) is a dominantly inherited disorder principally due to mutations in the low-density lipoprotein (LDL)-receptor pathway that causes markedly elevated plasma LDL-cholesterol concentration and premature coronary heart disease (CHD).1 In addition to elevated LDL-cholesterol levels, there is evidence that alterations in reverse cholesterol transport (RCT) may also contribute to accelerating atherosclerosis in FH.2 Excess cholesterol in macrophages...
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