Qijin Yin

Abstract Investigating cell morphology changes after perturbations using high-throughput image-based profiling is increasingly important for phenotypic drug discovery, including predicting mechanisms of action (MOA) and compound bioactivity. The vast space of chemical and genetic perturbations makes it impractical to explore all possibilities using conventional methods.

Abstract Identifying cis-regulatory elements (CREs) within non-coding genomic regions-such as enhancers, silencers, promoters, and insulators-is pivotal for elucidating the intricate gene regulatory mechanisms underlying complex biological traits. The current prevalent sequence-based methods often focus on singular CRE types, limiting insights into cell-type-specific biological implications.