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Qilong Ying on Muck Rack

Qilong Ying

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Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology

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By Patrizia Pessina, Mika Nevo, Junchao Shi, Emily Park, Nevan J. Krogan, Danielle L. Swaney, Qi Chen, Justin Brumbaugh, Qilong Ying
| Nature Verified
Abstract Controlling stem cell differentiation is a longstanding goal in biomedical research. Here we explore how cell fate is influenced by RNA condensates, specifically P-bodies, which modulate gene expression posttranscriptionally. We profiled the transcriptomes of biomolecular condensates in diverse developmental contexts spanning multiple vertebrate species. Our analyses revealed conserved, cell type-specific sequestration of untranslated RNAs encoding cell fate regulators.
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