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Qingla Zeng on Muck Rack

Qingla Zeng

As seen in: Frontiers in Immunology
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Articles

Mendelian susceptibility to mycobacterial disease: IFN-γ-driven immunity collapse underlies heterogeneous infections

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By Jingyu Zhou, Qinhua Zhou, Lingyun Shao, Wenhong Zhang, Mengqing Qian, Qingla Zeng, Qiaoling Ruan
| Frontiers in Immunology
Abstract Mendelian susceptibility to mycobacterial disease (MSMD) is a rare inborn error of immunity characterized by heightened susceptibility to low-virulence non-tuberculous mycobacteria. Despite the widespread application of next-generation sequencing, the molecular etiology of approximately 50% of patients remains elusive. To date, 22 genes have been implicated, all converging on the IL-12/23–IFN-γ circuit, underscoring its non-redundant role in controlling intracellular pathogens.
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