Qinxian Guo

Introduction Deafness is one of the most common human health problems, affecting one in 1000 newborns.1 It is anticipated that the number of deaf people will be more than 28 million by the end of 2030 in the US.2 To date, the etiology of hearing loss is not well understood, but increasing evidence has suggested that deafness can be caused by genetic and environmental factors.3 In fact, the genetic impact has been found more than 50% patients with hearing loss.

Abstract : Type 2 diabetes mellitus (T2DM) is a common endocrine disorder which remains a large challenge for clinicians. Previous studies have suggested that mitochondrial dysfunction plays an active role in T2DM progression, but a detailed mechanism is still elusive. In the current study, two Han Chinese families with maternally inherited T2DM were evaluated using clinical, genetic, molecular, and biochemical analyses. The mitochondrial genomes were PCR amplified and sequenced.