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Qinying Yu

As seen in: Nature, ACS Publications
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Articles

Development of LRRC15-binding disulfide-constrained peptides for PET imaging of cancer-associated fibroblasts

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By Benjamin J Tombling, Fei Cai, Timothy J Wendorff, Annie Ogasawara, Herman Gill, Andrew Chang, Aaron T. Balana, Lingling Peng, Stephen MIller, Stephen Miller, Benjamin T. Walters, Aaron Lictao, Qinying Yu, David DeWitt Verified, Yuehua Wei, Sunny Wu, Jawahar Sudhamsu, Akshay T Krishnamurty, Simon Williams Verified, Jan Marik, Yingnan Zhang, Henry R Maun, Daniel Kirchhofer, Jeff N. Tinianow
| Nature Verified
Abstract Leucine-rich-repeat-containing protein 15 (LRRC15) is selectively expressed on cancer-associated fibroblasts (CAFs) and constitutes a promising biomarker for imaging the tumor microenvironment. Using a combinatorial library approach, assisted by machine learning, we developed disulfide-constrained peptides (DCPs), notably ML-YSD-07 and ML-PD-03, that demonstrate subnanomolar affinities for murine LRRC15 (muLRRC15) and specifically localize onto muLRRC15-expressing fibroblasts.
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Elucidating Molecular Mechanisms of Drug-Induced Hepatotoxicity of Lapatinib

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By Qinying Yu, Li Ma, Peter S. Dragovich, Leah M. Norona
| ACS Publications
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Elucidating Molecular Mechanisms of Drug-Induced Hepatotoxicity of Lapatinib

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By Qinying Yu, Li Ma, Leah M. Norona, Peter S. Dragovich
| dx.doi.org
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