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PTEN inhibitor attenuates cardiac fibrosis by regulating the M2 macrophage phenotype via the PI3K/AKT/TGF-β/Smad 2/3 signaling pathway
Highlights • VO-OHpic suppresses pro-inflammation M1 macrophages and activates anti-inflammatory M2 macrophages. • VO-OHpic ameliorates cardiac fibrosis by regulating macrophage phenotype. • The PI3K/AKT/TGF-β/Smad 2/3 pathway plays a critical role in the relationship between VO-OHpic and macrophage phenotype on cardiac fibrosis. Abstract Cardiac fibrosis is a key feature of hypertensive cardiac remodeling.
The most basal ankylosaurine dinosaur from the Albian-Cenomanian of China, with implications for the evolution of the tail club
Etymology: The generic name derives from ‘Jinyun’ (Mandarin) in reference to Jinyun County in which the type locality is located, and ‘pelta’ (Latin), a small shield, in reference to the osteoderms found on all ankylosaurians. The root of the specific name ‘sin’ (Greek) refers to China, the country of origin.
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