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Qiuni Luo

As seen in: Nature
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Articles by Qiuni Luo

Intracellular C3 modulates senolytic responsiveness in senescent cells and aged tissues via AKT/S6K pro-survival signaling

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By Runzi Zheng, Michael Okeke, Zhen Zhou, Ayesha Nisar, Jing J. Liu, Yonghan He, Naheemat Modupeola Gold, Qiuni Luo
| Nature Verified
Abstract Pathological accumulation of senescent cells (SnCs) across tissues drives aging and age-related diseases. Senolytic agents targeting senescent cell anti-apoptotic pathways (SCAPs) hold promise for treating age-related diseases, yet their efficacy is limited by the heterogeneity of SnC survival mechanisms beyond canonical BCL-2 family pathways. Here, we identify intracellular complement C3 (intC3) as a previously unrecognized determinant of senolytic responsiveness.
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