Qiushi Yin
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Bidirectional longitudinal associations between low anterior resection syndrome and stigma in patients with postoperative LARS: a cross-lagged panel study
Abstract Objective: To investigate the bidirectional longitudinal associations between low anterior resection syndrome (LARS) and stigma among patients with postoperative LARS following sphincter-preserving surgery for rectal cancer. Methods: A total of 201 patients with LARS after sphincter-preserving surgery for rectal cancer were recruited using convenience sampling between March 2024 and June 2025. Follow-up was completed in December 2025.
HBx Drives Liver Cancer Stem Cell Generation Through Stimulating Glucose Metabolic Reprogramming
AFP alpha-fetoprotein ATP adenosine triphosphate CSCs cancer stem cells EpCAM epithelial cellular adhesion molecule GAPDH glyceraldehyde 3-phosphate dehydrogenase GLUTs glucose transporters HBx hepatitis B virus x protein HCC hepatocellular carcinoma hESCs human embryonic stem cells HK2 Hexokinase2 LCSCs liver cancer stem cells LDH lactate dehydrogenase LDHA lactate dehydrogenase A mTOR mammalian target of rapamycin PI3K/Akt phosphatidylinositol 3-kinase/protein kinase B PKM2 pyruvate kinase...
EZH2‐Mediated PHF10 Suppression Amplifies HMGB1/NF‐κB Axis That Confers Chemotherapy Resistance in Cholangiocarcinoma
1 Introduction Cholangiocarcinoma (CHOL), also known as bile duct cancer, is a relatively rare but aggressive form of cancer that originates in the cells of the bile ducts [1]. In most cases, surgical resection remains the only curative option [2]. However, the majority of patients present at an advanced stage when not amenable to surgical resection [3]. Gemcitabine and cisplatin are most widely used chemotherapeutic agents for CHOL.
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