Qiying Yao

1 INTRODUCTION Previous studies have indicated that chronic uncontrolled hypertension is a common cause of pathological myocardial hypertrophy, which often leads to heart failure, arrhythmia, and sudden death.1-3 Under long-term stimulation by mechanical or neurohumoral factors, fetal genes in myocardial nuclei are activated, resulting in cardiac structural remodelling.3, 4 Numerous transgenic and gene knockout animal studies, alongside clinical case reports, have demonstrated that heightened...