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Qiying Ye

As seen in: Nature, Wiley Online Library, Science Magazine, BioRxiv
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Articles

Vascular dementia: novel insights through multiscale mechanistic modeling - Signal Transduction and Targeted Therapy Original

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By Qiying Ye, Dongming Cai
| Nature Verified
In a recent study published in Cell1 that combines cell-type-specific transcriptomic profiles generated from a novel vascular dementia (VaD) mouse model with a human VaD single-nuclei RNA-sequencing (sn-RNA-seq) dataset, dysregulated intercellular signaling targets of white matter injury were identified and further validated in vivo. This study opens new directions for future development of biomarkers and/or therapeutics for VaD.
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Multiple cholinergic receptor subtypes coordinate dual modulation of acetylcholine on anterior and posterior paraventricular thalamic neurons

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By Qiying Ye, Jeremiah Nunez, xiaobing Zhang
| Wiley Online Library Verified
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interests. REFERENCES , , , , , , & (2018). Basal forebrain and brainstem cholinergic neurons differentially impact amygdala circuits and learning-related behavior. Current Biology, 28, 2557–2569.e4. , , , , , , & (1995). Nicotinic receptor function in the mammalian central nervous system. Annals of the New York Academy of Sciences, 757, 48–72. , & (1999).
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Zona incerta dopamine neurons encode motivational vigor in food seeking

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By Bjorn Tytgat, Coral K. Wille, Yunshu Che, Qiying Ye
| Science Magazine Verified
Abstract Energy deprivation triggers food seeking to ensure homeostatic consumption, but the neural coding of motivational vigor in food seeking during physical hunger remains unknown. Here, we report that ablation of dopamine (DA) neurons in zona incerta (ZI) but not ventral tegmental area potently impaired food seeking after fasting. ZI DA neurons and their projections to paraventricular thalamus (PVT) were quickly activated for food approach but inhibited during food consumption.
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