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Qiying Yi on Muck Rack

Qiying Yi

As seen in: Nature
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An epigenetic switch in β -cells links mitochondrial stress to inflammatory fate via HMGB1 acetylation

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By Yao Cheng, Luyao Wang, Xue Bai, Guoqi Zhu, Ying Xu, Bin Wang, Guangneng Liao, Jinglan Huang, Dan Wang, Sirong He, Qiying Yi
| Nature Verified
Summary Pancreatic β-cell failure in diabetes is driven by chronic inflammation, yet how metabolic stress determines pro-inflammatory cell fate remains unclear. Here, we report that sublethal oxidative stress activates a β-cell-enriched epigenetic switch that licenses intrinsic inflammation. We identify a β-cell-enriched vulnerability wherein oxidative stress disrupts mitochondrial NAD⁺/acetyl-CoA flux, skewing the nuclear equilibrium between the deacetylase SIRT1 and acetyltransferases p300/CBP.
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