Qiying Zhu

Abstract Preeclampsia (PE) is a placenta-driven hypertensive disorder characterized by oxidative stress, mitochondrial dysfunction, and abnormal autophagy. However, how these stress-response programs are coordinated at the post-transcriptional level remains incompletely understood. We integrated transcriptomic, proteomic, and untargeted metabolomic profiling of placentas from PE patients and normotensive controls, followed by validation in an independent clinical cohort.

Abstract Preterm birth (PTB), a complication affecting 5% to 11.1% of pregnancies worldwide, imposes adverse consequences for both families and society. Previous studies have revealed that interleukin-37(IL-37) is involved in PTB in foetal membranes and that NLRP3 inflammasome activation promotes labour. However, the direct effects of IL-37 on PTB, as well as the underlying mechanisms, remain unclear.

Conflicts of Interest The authors declare no conflicts of interest. References , , , , and . 2018. “The Role of Oxidative Stress in the Development of Systemic Sclerosis Related Vasculopathy.” Frontiers in Physiology 9: 1177. 2015. “Gestational Diabetes Mellitus.” Saudi Medical Journal 36: 399–406. , , , et al. 2017. “Gestational Diabetes Alters Functions in Offspring's Umbilical Cord Cells With Implications for Cardiovascular Health.” Endocrinology 158: 2102–2112. , , , et al. 2022.