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Surface coupling strength of gold nanoparticles affects cytotoxicity on neurons

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By Ulrich Simon, Quang Anh Tran, Corinna Kaulen, Andreas Offenhäusser
| Royal Society of Chemistry Verified
Gold nanoparticles (AuNPs) are versatile nanomaterials which are frequently used to manipulate and study cellular behavior on nanometer scale. However, it has been recognized that freely diffusing, colloidal particles can possess severe cytotoxicity. One strategy to overcome this harmful side effect is to tether the nanoparticles to sample surfaces. In this study, the cytotoxicity of immobilized AuNPs is investigated as a function of their sizes, surface density, and binding strength.
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