Quanpu Wang

Palladium/XuPhos-Catalyzed Enantioselective Cascade Heck/ Intermolecular C(sp2)−H Alkylation Reaction Palladium-catalyzed enantioselective domino Heck/intramolecular C-H functionalization reaction, as a valuable strategy for creating molecular diversity, has remained a prominent challenge. Here, we describe a Pd/XuPhos catalyst for asymmetric domino Heck/intermolecular C-H alkylation of unactivated alkenes with diverse polyfluoroarenes in a highly chemo-, and enantioselective manner.

Recent advances in Pd-catalyzed asymmetric cyclization reactions Over the past few decades, there have been major developments in transition metal-catalyzed asymmetric cyclization reactions, enabling the convenient access to a wide spectrum of structurally diverse chiral carbo- and hetero-cycles, common skeletons found in fine chemicals, natural products, pharmaceuticals, agrochemicals, and materials.