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Quiying Chen on Muck Rack

Quiying Chen

As seen in: BioRxiv
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Articles

Rescuing Ischemic Brain Injury by Rewiring Mitochondrial Electron Flow

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By Belem Yoval-Sánchez, Iván Guerrero, Sergei Sosunov, Quiying Chen
| BioRxiv
Abstract Mitochondrial metabolic flux alterations are critical drivers of acute ischemia-reperfusion (IR) brain injury. Reverse electron transfer (RET), defined as the upstream flow of electrons from the quinone pool to complex I, is a major source of pathological reactive oxygen species (ROS) under stress conditions. Using an in vivo model of brain IR, we show that RET-supporting substrates (succinate and glycerol 3-phosphate) accumulate during oxygen deprivation.
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