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Prognostic significance of IDH1 promoter methylation and associated genome-wide alterations in breast cancer

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By Summayya Anwar, Azam Khan, Sadia Yasmin, Qurat ulain, Erum Najeeb, Muhammad A. Saeed, Alfar Ahmad, Mirza Imran Shahzad
| Nature Verified
Abstract Dysregulation of IDH1, a key metabolic enzyme, is widely reported across cancers and affects both tumor biology and patient prognosis. However, its regulation and associated epigenetic alterations in breast cancer (BC) remain unclear. This study examined methylation of two CpG islands (I1, I2) within the IDH1 promoter and a putative distal enhancer in clinical BC samples, correlating these patterns with IDH1 expression and clinicopathological features.
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