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R. Dayne Mayfield on Muck Rack

R. Dayne Mayfield

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

Alcohol induces concentration‐dependent transcriptomic changes in oligodendrocytes

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By Sam A. Bazzi, Cole Maguire, R. Dayne Mayfield, Esther Melamed
| Wiley Online Library Verified
1 INTRODUCTION Oligodendrocytes (OLs) are glial cells within the central nervous system (CNS) that produce myelin, which coats neuronal axons and enhances the fast propagation of neuronal signals.
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Divergent gene expression patterns in alcohol and opioid use disorders lead to consistent alterations in functional networks within the dorsolateral prefrontal cortex | Translational Psychiatry

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By Erin Murray, Rachel L. Kember, R. Dayne Mayfield
| Nature Verified
Abstract Substance Use Disorders (SUDs) manifest as persistent drug-seeking behavior despite adverse consequences, with Alcohol Use Disorder (AUD) and Opioid Use Disorder (OUD) representing prevalent forms associated with significant mortality rates and economic burdens. The co-occurrence of AUD and OUD is common, necessitating a deeper comprehension of their intricate interactions. While the causal link between these disorders remains elusive, shared genetic factors are hypothesized.
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Gene expression differences associated with alcohol use disorder in human brain - Molecular Psychiatry

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By Caryn Willis, Julie White, Melyssa Minto, Shizhong Han, Joo Heon Shin, Thomas Hyde, R. Dayne Mayfield, Bradley Webb, Eric Johnson, Joel E. Kleinman, Laura J. Bierut
| Nature Verified
Abstract Excessive alcohol consumption is a leading cause of preventable death worldwide. To improve understanding of neurobiological mechanisms associated with alcohol use disorder (AUD) in humans, we compared gene expression data from deceased individuals with and without AUD across two addiction-relevant brain regions: the nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC).
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