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R. J. Barst on Muck Rack

R. J. Barst

As seen in: European Respiratory Journal
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Articles

Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2

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By M. Humbert, R. J. Barst, R. Channick, I. M. Robbins
| European Respiratory Journal Verified
Abstract The efficacy and safety of combining bosentan, an orally active dual endothelin receptor antagonist and epoprostenol, a continuously infused prostaglandin, in the treatment of pulmonary arterial hypertension (PAH) was investigated.
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Survival with first-line bosentan in patients with primary pulmonary hypertension

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By V. McLaughlin, O. Sitbon, D. B. Badesch, R. J. Barst
| European Respiratory Journal Verified
Abstract Primary pulmonary hypertension (PPH) is a progressive disease with high mortality. Administration of i.v. epoprostenol has demonstrated improved exercise tolerance, haemodynamics, and survival. The orally active, dual endothelin receptor antagonist bosentan improves exercise endurance, haemodynamics, and functional class over the short term.
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