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R. Keith Duncan on Muck Rack

R. Keith Duncan

Wayne
As seen in: Stem Cell Reports
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Articles

Retinoic acid signaling guides the efficiency of inner ear organoid-genesis and governs sensory-nonsensory fate specification

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By Liqian Liu, Mo Moyer, Andrew A. Wylie, Luis R Cassinotti, R. Keith Duncan, Ranya Dano
| Stem Cell Reports Verified
Keywords inner ear organoid RNA-seq hair cells retinoic acid TGF-β embryonic stem cell fate specification anterior-posterior axis Introduction Three-dimensional organoid culture systems provide a unique parallel approach to in vivo inner ear research. These culture systems are accessible throughout the differentiation process, scalable to high-throughput technologies, and easy to manipulate, opening new paths to study development, disease, therapeutics, and regeneration.
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