Under a Creative Commons license open access Keywords Mitochondrial fission Mitochondrial dynamics Insulin sensitivity Mitochondrial H 2O2 Abbreviations WT Wild type mDrp1+/− Skeletal muscle-specific heterozygous tamoxifen-induced Drp1 partial knockout mice Drp1 Dynamin-related protein 1 MFF Mitochondrial fission factor Mid51 Mitochondrial dynamics proteins of 51 kDa Fis1 Fission protein 1 Mfn1 Mitofusin 1 Mfn2 Mitofusin 2 Opa1 Optic atrophy 1 HFD High-fat diet LFD Low-fat diet ROS Reactive...