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Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Link R, Jaggy M, Bastmeyer M, Schwarz US (2024) Modelling cell shape in 3D structured environments: A quantitative comparison with experiments. PLoS Comput Biol 20(4): e1011412.

1 Introduction During the last decades, cell mechanics, forces, and shape have emerged as important elements of the way biological cells interact with their environment.[1] While the importance of control of cells through biochemical ligands such as growth factors, hormones, and cytokines has been appreciated from the very start of cell culture experiments, the insight that spatial control of cell adhesion, the physical properties of the extracellular matrix as well as the mechanics of the...