Rabeaa Aborgies on Muck Rack

Rabeaa Aborgies

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Articles

Mesenchymal stromal cells modulate survival and regeneration of human hematopoietic stem cells via PGE2/cAMP signaling - Cell Death & Disease

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By Chen Katz-Even, Adi Zipin-Roitman, Diana Rasoulouniriana, Debanjan Roy, Katia Beider, Yael Raz, Neta Solomon, Yael Shulman, Rony Chen, Eviatar Weizman, Claudia Waskow, Arnon Nagler, Michael Milyavsky, Rabeaa Aborgies, Gal Hershkovitz
| Nature Verified
Abstract Ionizing radiation and chemotherapy significantly impair hematopoietic stem and progenitor cell (HSPC) function, increasing the risk of bone marrow failure and secondary malignancies. Mesenchymal stromal cells (MSCs), critical regulators within the hematopoietic niche, maintain HSPC quiescence, self-renewal, survival, and differentiation. However, the specific pro-regenerative signaling pathways activated by MSCs in human HSPCs remain incompletely defined.
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