Rabia Gül Aydin on Muck Rack

Rabia Gül Aydin

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Nuclear localization of MTHFD2 is required for correct mitosis progression - Nature Communications

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By Anestis Gkanogiannis, Antoni Ganez Zapater, Lorena Espinar, Ritobrata Ghose, Jacqueline Severino, Laura Martin, Maria Victoria Neguembor, Maria Pia Cosma, Rabia Gül Aydin
| Nature Verified
Abstract Subcellular compartmentalization of metabolic enzymes establishes a unique metabolic environment that elicits specific cellular functions. Indeed, the nuclear translocation of certain metabolic enzymes is required for epigenetic regulation and gene expression control. Here, we show that the nuclear localization of the mitochondrial enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) ensures mitosis progression.
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