Rabih Abou Farraj on Muck Rack

Rabih Abou Farraj

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Hyperacute Response Proteins (HARPs) synthesized on γ-tubulin-FTO-MARK4 translation microdomains upon exposure to stress, regulate stress response in cancer.

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By Bruno Saleme, Saymon Tejay, Paul Dembele, Rabih Abou Farraj
| biorxiv.org
Abstract Compared to normal, cancer cells are particularly resistant to stress, and their immediate response to stress is critical for their subsequent multilayered adaptation programs which pose a major clinical challenge. With unbiased proteomics and transcriptomics analysis, we identified a list of HARPs synthesized from pre-existing mRNAs within 20 min of diverse stresses in A549 cancer cells, despite the known suppressed global translation in stress.
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