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Rachel DeBarge on Muck Rack

Rachel DeBarge

As seen in: BioRxiv
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Articles

A mass cytometry approach to track the evolution of T cell responses during infection and immunotherapy by paired T cell receptor repertoire and T cell differentiation state analysis

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By Jesse Castillo, Iliana Tenvooren, Rachel DeBarge, Abigail Mende
| BioRxiv
Abstract T cell receptor (TCR) recognition followed by clonal expansion is a fundamental feature of adaptive immune responses. Here, we developed a mass cytometric (CyTOF) approach combining antibodies specific for different TCR Vα- and Vβ-chains with antibodies against T cell activation and differentiation proteins to identify antigen-specific expansions of T cell subsets and assess aspects of cellular function.
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