Rachel HH Ching on Muck Rack

Rachel HH Ching

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SARS-CoV-2 Omicron BA.2.86 and JN.1 expand tropism in human proximal intestinal epithelium

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By Kenrie Hui, Ka-chun Ng, Jenny Chan , Taylor Ho, Leo LM Poon, Malik Peiris, John Nicholls, Michael Chan, John CW Ho, Rachel HH Ching
| Nature
Abstract Omicron SARS-CoV-2 has diversified into multiple sub-lineages, complicating assessment of their intrinsic phenotypes due to background population immunity. We compare replication and biological characteristics of variants from BA.1 to JN.1 using human bronchial and lung explants, airway organoids, colon cells, and proximal intestinal enteroids. XBB.1.5 and EG.5.1 achieve higher replication titres in respiratory tissues than BA.2.86 and JN.1, indicating enhanced respiratory fitness.
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