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Rachel Plumb

As seen in: Cell Reports
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Articles by Rachel Plumb

Gifted deposits for house purchases

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By Rachel Plumb
| brachers.co.uk
Insight - Property and Conveyancing - POSTED: November 22 2023 Share this article Now with ever increasing numbers of purchasers using funds from family to help get them on the housing ladder, it’s important that all parties are aware of the complexities and the risks involved.
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A guide to remortgaging your property

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By Rachel Plumb
| brachers.co.uk
Insight - Property and Conveyancing - POSTED: June 30 2023 Share this article Print this article This guide is for anyone who already has a mortgage on their home and are considering finding another mortgage deal. Perhaps you are coming towards the end of your current deal, you want to cut costs, release funds or consolidate your debts. Our guide will help you to understand the steps to take to ensure your remortgage is as smooth as possible. What is a remortgage?
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A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress

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By Xia Li, Suhila Appathurai, Arunkumar Sundaram, Rachel Plumb
| Cell Reports Verified
Highlights • IRE1α forms an ER-stress-independent complex with the Sec61/Sec63 translocon • IRE1α binding to BiP chaperone relies on its association with Sec61/Sec63 • Sec63 attenuates IRE1α signaling by mediating BiP binding to IRE1α during ER stress • IRE1α remains activated in Sec63-deficient cells during prolonged ER stress Summary Misfolded proteins in the endoplasmic reticulum (ER) activate IRE1α endoribonuclease in mammalian cells, which mediates XBP1 mRNA splicing to produce an active...
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