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Rachita Dash

As seen in: Nature, BioRxiv
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Articles

Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning

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By Irene Lepori, Zichen Liu, Nelson Evbarunegbe, Shasha Feng, Turner P. Brown, Kishor Mane, Rachita Dash, Mitchell Wong, Amir George, Taijie Guo, Anil M. Shelke, K. Barry Sharpless, Jiajia Dong, Joel S. Freundlich, Wonpil Im, Anna Green, Marcos M. Pires, M. Siegrist, Ananya Naick
| Nature Verified
Abstract The ability of compounds to permeate and accumulate in bacterial cells is a critical determinant of antibiotic efficacy. Better therapeutics are urgently needed for the human pathogen Mycobacterium tuberculosis, yet the cell envelope, including the mycobacterial outer membrane, represents a significant barrier for drug entry, and the chemical features governing permeation remain poorly understood.
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Systematic Determination of the Impact of Structural Edits on Peptide Accumulation into Mycobacteria

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By Rachita Dash, Zichen Liu, Irene Lepori, Mahendra D. Chordia
| dx.doi.org
Introduction Click to copy section linkSection link copied! Tuberculosis (TB) is a major global public health concern, with over 10 million cases reported worldwide in 2022. (1) Often recognized as the deadliest infectious disease, TB has recently seen a surge in incidence, reversing a decade-long trend of decline. (2) The causative agent of TB is Mycobacterium tuberculosis (Mtb).
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Profiling Cytosolic Drug Delivery in Mammalian Cells: A Generalizable Assay for Intracellular Accumulation

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By George M. Ongwae, Rachita Dash, Zichen Liu, Sobika Bhandari
| BioRxiv
Abstract The ability of biologically active molecules to access intracellular targets remains a critical barrier in drug development. While assays for measuring cellular uptake exist, they often fail to distinguish between membrane-associated or endosomal trapped compounds and those that successfully reach the cytosol.
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