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Radostina Lyutova on Muck Rack

Radostina Lyutova

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Reward signaling in a recurrent circuit of dopaminergic neurons and peptidergic Kenyon cells

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By Radostina Lyutova, Mareike Selcho, Dennis Segebarth, Jens Habenstein
| Nature Verified
Abstract Dopaminergic neurons in the brain of the Drosophila larva play a key role in mediating reward information to the mushroom bodies during appetitive olfactory learning and memory. Using optogenetic activation of Kenyon cells we provide evidence that recurrent signaling exists between Kenyon cells and dopaminergic neurons of the primary protocerebral anterior (pPAM) cluster. Optogenetic activation of Kenyon cells paired with odor stimulation is sufficient to induce appetitive memory.
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