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Rafael José Argüello on Muck Rack

Rafael José Argüello

As seen in: Nature
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Articles

Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions - Nature Metabolism

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By Yu-San Kao, Aleksandra Król, Rafael José Argüello, Luana Faria Silva, Lydia Lynch, Karsten Hiller, Kathrin Luise Braband, Assel Nurbekova
| Nature Verified
Abstract Metabolic reprogramming determines γδ T cell fate during thymic development; however, the metabolic requirements of interleukin (IL)-17A-producing γδ T cells (γδT17 cells) under psoriatic conditions are unclear. Combining high-throughput techniques, including RNA sequencing, SCENITH, proteomics and stable isotope tracing, we demonstrated that psoriatic inflammation caused γδT17 cells to switch toward aerobic glycolysis.
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Immunosenescence and vaccine efficacy revealed by immunometabolic analysis of SARS-CoV-2-specific cells in multiple sclerosis patients - Nature Communications

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By Sara De Biasi, Moritz Rau, Nikolaos Paschalidis, Lara Gibellini, Alin Liviu Ciobanu, Ignacio Rubio, Martina Cardi, Rafael José Argüello
| Nature Verified
Abstract Disease-modifying therapies (DMT) administered to patients with multiple sclerosis (MS) can influence immune responses to SARS-CoV-2 and vaccine efficacy. However, data on the detailed phenotypic, functional and metabolic characteristics of antigen (Ag)-specific cells following the third dose of mRNA vaccine remain scarce.
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