Rafal Bartoszewski

4. Ub-Dependent versus Ub-Independent Protein Degradation Overall, the presence of intrinsically disordered regions explains the susceptibility of some proteins, especially intrinsically disordered proteins (IDPs), to proteasomal degradation. These proteins differ in many ways from folded proteins. For instance, while the attachment of Ub reduces the thermal stability of folded proteins, thermotolerant IDPs are readily processed by 20S proteasome [59].

Abstract : Simple Summary In this review, we discuss how miRNAs play a critical role in the regulation of mRNA stability and translation, how determining the direct targets of miRNAs in complex networks is extremely difficult, and how translating specific miRNAs to the clinic often results in failure. This has led to concerns that this approach may not be feasible.

PerspectivesCall for Papers: The Pathophysiology of COVID-19 and SARS-CoV-2 Infection Rafal Bartoszewski, Michal Dabrowski, Bogdan Jakiela, Sadis Matalon, Kevin S. Harrod, Marek Sanak, and James F. Collawn Abstract Cold viruses have generally been considered fairly innocuous until the appearance of the severe acute respiratory coronavirus 2 (SARS-CoV-2) in 2019 which caused the coronavirus disease 2019 (COVID-19) global pandemic.